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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholic fatty liverdisease (NAFLD).However, the relationship between the changes in liver fat content and haemorheology is unknown.IHLC was quantified using proton magnetic resonance spectroscopy ( H-MRS) scanning of the liver.Diabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).patients with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetickidney disease (NADKD) or nonalbuminuric diabetic nephropathy.Epidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedWe aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liverdisease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuriawould be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a commoncause of liver cirrhosis and cancer.

Keywords： Akkermansia muciniphila     NAFLD     NASH     steatosis     inflammation    

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Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liverdisease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholic fatty liverdisease (NAFLD).

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: decoction on CD14 expression in the lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats.disease, and 25 of these 50 rats were treated with decoction simultaneously.Liver injury was evaluated by biochemical examination.decoction pretreatment significantly protected against acute alcohol-induced liver injury, which was

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

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Graft versus host disease after liver transplantation: A case report

Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 469-472 doi: 10.1007/s11684-010-0120-8

Abstract: In documenting clinical experience in the diagnosis and treatment of graft host disease (GVHD), we retrospectivelyanalyzed data of one case that has developed GVHD after liver transplantation.This patient exhibited fever, skin rash, and diarrhea on day 9 after liver transplantation.His liver function was normal.suggests that reducing the dosage of immunosuppressive agents can be an effective strategy for GVHD after liver

Keywords： liver transplantation     graft versus host disease    

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Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract:

Liver transplantation is the only life-saving procedure for patients with end-stage liver disease.These issues have prompted the search for new alternative therapies for irreversible liver disease.and improved survival rates in experimental models of liver disease.This review summarizes the general understanding of the therapeutic potentials of stem cells in liverdisease, including the sources, mechanisms, and delivery methods of hepatic stem cells in liver regeneration

Keywords： stem cell     liver disease     regenerative medicine    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 389-396 doi: 10.1007/s11684-016-0468-5

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinomagene expression, and the dysregulation of miRNAs is involved in various biological processes in the livermiRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver

Keywords： nonalcoholic fatty liver disease     nonalcoholic steatohepatitis     hepatocellular carcinoma     miRNA    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in thecontext of obesity worldwide, which contains a spectrum of chronic liver diseases, including hepaticaddition to the classical “Two-hit” theory, NAFLD has been recognized as a typical gut microbiota-related diseasebecause of the intricate role of gut microbiota in maintaining human health and disease formation.Moreover, gut microbiota is even regarded as a “metabolic organ” that play complementary roles to that of liver

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAyAdditionally, XKQ can significantly decrease the serum alanine aminotransferase level and liver indexand can alleviate the fat degeneration in liver tissues.

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Title Author Date Type Operation

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Journal Article

Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liverdisease: a translational approach

Journal Article

decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article

Graft versus host disease after liver transplantation: A case report

Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article